6S69
Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor
Summary for 6S69
Entry DOI | 10.2210/pdb6s69/pdb |
Related | 6S60 |
Descriptor | Transcriptional enhancer factor TEF-4, MYRISTIC ACID, 3-[3-(3,4-dichlorophenyl)-4-(2-phenylethylcarbamoyl)pyrazol-1-yl]propanoic acid, ... (4 entities in total) |
Functional Keywords | tead2, inhibitor, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 55867.23 |
Authors | Sturbaut, M.,Allemand, F.,Guichou, J.F. (deposition date: 2019-07-02, release date: 2020-07-22, Last modification date: 2022-02-02) |
Primary citation | Sturbaut, M.,Bailly, F.,Coevoet, M.,Sileo, P.,Pugniere, M.,Liberelle, M.,Magnez, R.,Thuru, X.,Chartier-Harlin, M.C.,Melnyk, P.,Gelin, M.,Allemand, F.,Guichou, J.F.,Cotelle, P. Discovery of a cryptic site at the interface 2 of TEAD - Towards a new family of YAP/TAZ-TEAD inhibitors. Eur.J.Med.Chem., 226:113835-113835, 2021 Cited by PubMed: 34509860DOI: 10.1016/j.ejmech.2021.113835 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
Download full validation report