6S5U

Strictosidine Synthase from Ophiorrhiza pumila in complex with N-[2-(1H-Indol-3-yl)ethyl]-3-methyl-1-butanamine

Summary for 6S5U

Entry DOI	10.2210/pdb6s5u/pdb
Descriptor	Strictosidine synthase, ~{N}-[2-(1~{H}-indol-3-yl)ethyl]-3-methyl-butan-1-amine (3 entities in total)
Functional Keywords	alkaloid, c-c bond, pictet-spenglerase, lyase
Biological source	Ophiorrhiza pumila
Total number of polymer chains	6
Total formula weight	223613.95
Authors	Eger, E.,Sharma, M.,Kroutil, W.,Grogan, G. (deposition date: 2019-07-02, release date: 2020-04-08, Last modification date: 2024-01-24)
Primary citation	Eger, E.,Simon, A.,Sharma, M.,Yang, S.,Breukelaar, W.B.,Grogan, G.,Houk, K.N.,Kroutil, W. Inverted Binding of Non-natural Substrates in Strictosidine Synthase Leads to a Switch of Stereochemical Outcome in Enzyme-Catalyzed Pictet-Spengler Reactions. J.Am.Chem.Soc., 142:792-800, 2020 Cited by PubMed: 31909617 DOI: 10.1021/jacs.9b08704 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.03 Å)

Structure validation