6S5J

Strictosidine Synthase from Ophiorrhiza pumila in complex with (S)-1-Ethyl-2,3,4,9-tetrahydro-1H-beta-carboline

6S5J の概要

• エントリーDOI: 10.2210/pdb6s5j/pdb
• 分子名称: Strictosidine synthase, (1~{S})-1-ethyl-2,3,4,9-tetrahydro-1~{H}-pyrido[3,4-b]indole (3 entities in total)
• 機能のキーワード: alkaloid, c-c bond, pictet-spenglerase, lyase
• 由来する生物種: Ophiorrhiza pumila
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36970.18

構造登録者

Eger, E.,Sharma, M.,Kroutil, W.,Grogan, G. (登録日: 2019-07-01, 公開日: 2020-04-08, 最終更新日: 2024-01-24)

• 主引用文献: Eger, E.,Simon, A.,Sharma, M.,Yang, S.,Breukelaar, W.B.,Grogan, G.,Houk, K.N.,Kroutil, W.; Inverted Binding of Non-natural Substrates in Strictosidine Synthase Leads to a Switch of Stereochemical Outcome in Enzyme-Catalyzed Pictet-Spengler Reactions.; J.Am.Chem.Soc., 142:792-800, 2020; PubMed: 31909617; DOI: 10.1021/jacs.9b08704

実験手法

X-RAY DIFFRACTION (2.42 Å)