6S4N
LXRbeta ligand binding domain in comlpex with small molecule inhibitors
Summary for 6S4N
Entry DOI | 10.2210/pdb6s4n/pdb |
Descriptor | Oxysterols receptor LXR-beta, 2-[5-chloranyl-6-[4-[[1,1,3-tris(oxidanylidene)-5-phenyl-2-propan-2-yl-1,2-thiazol-4-yl]amino]piperidin-1-yl]pyridin-3-yl]ethanoic acid, SULFATE ION, ... (4 entities in total) |
Functional Keywords | liver x receptor beta, lxrb, lxr beta, nuclear hormone receptor, receptor ligand binding domain, nuclear protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 116815.08 |
Authors | Sandmark, J.,Jansson, A. (deposition date: 2019-06-28, release date: 2019-11-27, Last modification date: 2024-05-15) |
Primary citation | Belorusova, A.Y.,Evertsson, E.,Hovdal, D.,Sandmark, J.,Bratt, E.,Maxvall, I.,Schulman, I.G.,Akerblad, P.,Lindstedt, E.L. Structural analysis identifies an escape route from the adverse lipogenic effects of liver X receptor ligands. Commun Biol, 2:431-431, 2019 Cited by PubMed: 31799433DOI: 10.1038/s42003-019-0675-0 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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