6S4H

The crystal structure of glycogen phosphorylase in complex with 8

6S4H の概要

• エントリーDOI: 10.2210/pdb6s4h/pdb
• 分子名称: Glycogen phosphorylase, muscle form, (2~{R},3~{S},4~{R},5~{R},6~{S})-2-(hydroxymethyl)-6-(2-phenyl-1~{H}-imidazol-4-yl)oxane-3,4,5-triol, DIMETHYL SULFOXIDE, ... (5 entities in total)
• 機能のキーワード: phosphorylase, inhibitor, c-beta-d-glucopyranosyl imidazole, transferase
• 由来する生物種: Oryctolagus cuniculus (Rabbit)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 98053.99

構造登録者

Kyriakis, E.,Solovou, T.G.A.,Papaioannou, O.S.E.,Skamnaki, V.T.,Leonidas, D.D. (登録日: 2019-06-28, 公開日: 2020-02-19)

• 主引用文献: Kyriakis, E.,Karra, A.G.,Papaioannou, O.,Solovou, T.,Skamnaki, V.T.,Liggri, P.G.V.,Zographos, S.E.,Szennyes, E.,Bokor, E.,Kun, S.,Psarra, A.G.,Somsak, L.,Leonidas, D.D.; The architecture of hydrogen and sulfur sigma-hole interactions explain differences in the inhibitory potency of C-beta-d-glucopyranosyl thiazoles, imidazoles and an N-beta-d glucopyranosyl tetrazole for human liver glycogen phosphorylase and offer new insights to structure-based design.; Bioorg.Med.Chem., 28:115196-115196, 2020; PubMed: 31767404; DOI: 10.1016/j.bmc.2019.115196

実験手法

X-RAY DIFFRACTION (2.45 Å)