6S1L

Structure of fission yeast Mis16

6S1L の概要

• エントリーDOI: 10.2210/pdb6s1l/pdb
• 分子名称: Histone acetyltransferase type B subunit 2 (2 entities in total)
• 機能のキーワード: centromere mitosis wd40 histone chaperone, cell cycle
• 由来する生物種: Schizosaccharomyces pombe (Fission yeast)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 48407.41

構造登録者

Lefevre, S.,Korntner-Vetter, M.,Singleton, M.R. (登録日: 2019-06-19, 公開日: 2019-08-07, 最終更新日: 2024-01-24)

主引用文献

Korntner-Vetter, M.,Lefevre, S.,Hu, X.W.,George, R.,Singleton, M.R.
Subunit interactions and arrangements in the fission yeast Mis16-Mis18-Mis19 complex.
Life Sci Alliance, 2:-, 2019

PubMed Abstract: Centromeric chromatin in fission yeast is distinguished by the presence of nucleosomes containing the histone H3 variant Cnp1 Cell cycle-specific deposition of Cnp1 requires the Mis16-Mis18-Mis19 complex, which is thought to direct recruitment of Scm3-chaperoned Cnp1/histone H4 dimers to DNA. Here, we present the structure of the essential Mis18 partner protein Mis19 and describe its interaction with Mis16, revealing a bipartite-binding site. We provide data on the stoichiometry and overall architecture of the complex and provide detailed insights into the Mis18-Mis19 interface.

PubMed: 31371524
DOI: 10.26508/lsa.201900408

実験手法

X-RAY DIFFRACTION (1.94 Å)