6S14

Crystal Structure of DYRK1A with small molecule inhibitor

6S14 の概要

• エントリーDOI: 10.2210/pdb6s14/pdb
• 分子名称: Dual specificity tyrosine-phosphorylation-regulated kinase 1A, SULFATE ION, ~{N}-cyclopropyl-~{N}-methyl-4-pyrazolo[1,5-b]pyridazin-3-yl-pyrimidin-2-amine, ... (4 entities in total)
• 機能のキーワード: kinase, catalytic domain, phosphorylated, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42924.21

構造登録者

Sorrell, F.J.,Henderson, S.H.,Redondo, C.,Burgess-Brown, N.A.,von Delft, F.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.M.,Elkins, J.M. (登録日: 2019-06-18, 公開日: 2019-06-26, 最終更新日: 2024-01-24)

• 主引用文献: Sorrell, F.J.,Henderson, S.H.,Elkins, J.M.,Ward, S.; Kinase Scaffold Repurposing in the Public Domain; To be published,

実験手法

X-RAY DIFFRACTION (1.05 Å)