6RY4

PARP15 catalytic domain in complex with 4-(3-carbamoylphenoxy)benzamide.

Summary for 6RY4

• Entry DOI: 10.2210/pdb6ry4/pdb
• Descriptor: Protein mono-ADP-ribosyltransferase PARP15, 3-(4-aminocarbonylphenoxy)benzamide, DIMETHYL SULFOXIDE, ... (4 entities in total)
• Functional Keywords: inhibitor, mono-adp ribosyltransferase.., protein binding
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 45605.21

Authors

Murthy, S.N.,Maksimainen, M.M.,Lehtio, L. (deposition date: 2019-06-10, release date: 2020-07-15, Last modification date: 2024-05-29)

• Primary citation: Korn, P.,Classen, A.,Murthy, S.,Guareschi, R.,Maksimainen, M.M.,Lippok, B.E.,Galera-Prat, A.,Sowa, S.T.,Voigt, C.,Rossetti, G.,Lehtio, L.,Bolm, C.,Luscher, B.; Evaluation of 3- and 4-Phenoxybenzamides as Selective Inhibitors of the Mono-ADP-Ribosyltransferase PARP10.; Chemistryopen, 2021; PubMed: 34145784; DOI: 10.1002/open.202100087

Experimental method

X-RAY DIFFRACTION (1.95 Å)