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6RX5

Trypanosoma brucei PTR1 (TbPTR1) in complex with inhibitor 1 (NMT-C0003)

Summary for 6RX5
Entry DOI10.2210/pdb6rx5/pdb
Related6RX0
DescriptorPteridine reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, METHYL 1-(4-{[(2,4-DIAMINOPTERIDIN-6-YL)METHYL](METHYL)AMINO}BENZOYL)PIPERIDINE-4-CARBOXYLATE, ... (6 entities in total)
Functional Keywordstrypanosoma brucei, pteridine reductase, ptr1, tbptr1, pteridine based inhibitors, oxidoreductase
Biological sourceTrypanosoma brucei brucei
Total number of polymer chains4
Total formula weight127155.40
Authors
Landi, G.,Pozzi, C.,Mangani, S. (deposition date: 2019-06-07, release date: 2020-07-15, Last modification date: 2024-01-24)
Primary citationPohner, I.,Quotadamo, A.,Panecka-Hofman, J.,Luciani, R.,Santucci, M.,Linciano, P.,Landi, G.,Di Pisa, F.,Dello Iacono, L.,Pozzi, C.,Mangani, S.,Gul, S.,Witt, G.,Ellinger, B.,Kuzikov, M.,Santarem, N.,Cordeiro-da-Silva, A.,Costi, M.P.,Venturelli, A.,Wade, R.C.
Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1.
J.Med.Chem., 65:9011-9033, 2022
Cited by
PubMed: 35675511
DOI: 10.1021/acs.jmedchem.2c00232
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.42 Å)
Structure validation

221051

数据于2024-06-12公开中

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