6RWS
Fragment AZ-009 binding at the p53pT387/14-3-3 sigma interface
Summary for 6RWS
Entry DOI | 10.2210/pdb6rws/pdb |
Descriptor | 14-3-3 protein sigma, Cellular tumor antigen p53, 4-chloranyl-6-(sulfanylmethyl)-1-benzothiophene-2-carboximidamide, ... (5 entities in total) |
Functional Keywords | protein protein interaction, fragment soaking, stabilization, peptide binding protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 29941.12 |
Authors | Leysen, S.,Guillory, X.,Wolter, M.,Genet, S.,Somsen, B.,Patel, J.,Castaldi, P.,Ottmann, C. (deposition date: 2019-06-06, release date: 2020-06-17, Last modification date: 2024-01-24) |
Primary citation | Guillory, X.,Wolter, M.,Leysen, S.,Neves, J.F.,Kuusk, A.,Genet, S.,Somsen, B.,Morrow, J.K.,Rivers, E.,van Beek, L.,Patel, J.,Goodnow, R.,Schoenherr, H.,Fuller, N.,Cao, Q.,Doveston, R.G.,Brunsveld, L.,Arkin, M.R.,Castaldi, P.,Boyd, H.,Landrieu, I.,Chen, H.,Ottmann, C. Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63:6694-6707, 2020 Cited by PubMed: 32501690DOI: 10.1021/acs.jmedchem.9b01942 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.53 Å) |
Structure validation
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