6RWI

Fragment AZ-002 binding at the p53pT387/14-3-3 sigma interface

Summary for 6RWI

Entry DOI	10.2210/pdb6rwi/pdb
Descriptor	14-3-3 protein sigma, Cellular tumor antigen p53, 5-phenylthiophene-2-carboximidamide, ... (6 entities in total)
Functional Keywords	protein protein interaction, fragment soaking, stabilization, peptide binding protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	29951.00
Authors	Leysen, S.,Guillory, X.,Wolter, M.,Genet, S.,Somsen, B.,Patel, J.,Castaldi, P.,Ottmann, C. (deposition date: 2019-06-05, release date: 2020-06-17, Last modification date: 2024-01-24)
Primary citation	Guillory, X.,Wolter, M.,Leysen, S.,Neves, J.F.,Kuusk, A.,Genet, S.,Somsen, B.,Morrow, J.K.,Rivers, E.,van Beek, L.,Patel, J.,Goodnow, R.,Schoenherr, H.,Fuller, N.,Cao, Q.,Doveston, R.G.,Brunsveld, L.,Arkin, M.R.,Castaldi, P.,Boyd, H.,Landrieu, I.,Chen, H.,Ottmann, C. Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63:6694-6707, 2020 Cited by PubMed: 32501690 DOI: 10.1021/acs.jmedchem.9b01942 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation