6RUA
Structure of recombinant human butyrylcholinesterase in complex with a coumarin-based fluorescent probe linked to sulfonamide type inhibitor.
Summary for 6RUA
Entry DOI | 10.2210/pdb6rua/pdb |
Related | 5DYT |
Descriptor | Cholinesterase, diethyl-[6-[[2-[2-[2-[naphthalen-2-ylsulfonyl-[[(3~{R})-1-(phenylmethyl)piperidin-3-yl]methyl]amino]ethoxy]ethoxy]ethylamino]-oxidanyl-methyl]-7-oxidanylidene-1,3,4,4~{a},5,6,8,8~{a}-octahydronaphthalen-2-ylidene]azanium, TRIETHYLENE GLYCOL, ... (12 entities in total) |
Functional Keywords | human butyrylcholinesterase, insect cell, hydrolase, fluorescent probes, sulfonamide, inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 137887.74 |
Authors | Coquelle, N.,Knez, D.,Brus, B.,Gobec, S.,Colletier, J.P. (deposition date: 2019-05-27, release date: 2020-01-22, Last modification date: 2024-01-24) |
Primary citation | Pajk, S.,Knez, D.,Kosak, U.,Zorovic, M.,Brazzolotto, X.,Coquelle, N.,Nachon, F.,Colletier, J.P.,Zivin, M.,Stojan, J.,Gobec, S. Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes. J Enzyme Inhib Med Chem, 35:498-505, 2020 Cited by PubMed: 31914836DOI: 10.1080/14756366.2019.1710502 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
Download full validation report