6RUA

Structure of recombinant human butyrylcholinesterase in complex with a coumarin-based fluorescent probe linked to sulfonamide type inhibitor.

6RUA の概要

• エントリーDOI: 10.2210/pdb6rua/pdb
• 関連するPDBエントリー: 5DYT
• 分子名称: Cholinesterase, diethyl-[6-[[2-[2-[2-[naphthalen-2-ylsulfonyl-[[(3~{R})-1-(phenylmethyl)piperidin-3-yl]methyl]amino]ethoxy]ethoxy]ethylamino]-oxidanyl-methyl]-7-oxidanylidene-1,3,4,4~{a},5,6,8,8~{a}-octahydronaphthalen-2-ylidene]azanium, TRIETHYLENE GLYCOL, ... (12 entities in total)
• 機能のキーワード: human butyrylcholinesterase, insect cell, hydrolase, fluorescent probes, sulfonamide, inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 137887.74

構造登録者

Coquelle, N.,Knez, D.,Brus, B.,Gobec, S.,Colletier, J.P. (登録日: 2019-05-27, 公開日: 2020-01-22, 最終更新日: 2024-01-24)

• 主引用文献: Pajk, S.,Knez, D.,Kosak, U.,Zorovic, M.,Brazzolotto, X.,Coquelle, N.,Nachon, F.,Colletier, J.P.,Zivin, M.,Stojan, J.,Gobec, S.; Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes.; J Enzyme Inhib Med Chem, 35:498-505, 2020; PubMed: 31914836; DOI: 10.1080/14756366.2019.1710502

実験手法

X-RAY DIFFRACTION (2.75 Å)