6RSR

TBK1 in complex with compound 2

6RSR の概要

• エントリーDOI: 10.2210/pdb6rsr/pdb
• 分子名称: Serine/threonine-protein kinase TBK1, ~{N}-(cyclopropen-1-ylmethyl)-2-[[4-[[4-[3,3,3-tris(fluoranyl)propanoyl]piperazin-1-yl]methyl]pyridin-2-yl]amino]-1~{H}-benzimidazole-5-carboxamide (2 entities in total)
• 機能のキーワード: kinase, innate immunity, small molecule inhibitor, immune system
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 76683.57

構造登録者

Panne, D.,Hillig, R.C.,Rengachari, S. (登録日: 2019-05-22, 公開日: 2020-01-01, 最終更新日: 2024-05-15)

• 主引用文献: Lefranc, J.,Schulze, V.K.,Hillig, R.C.,Briem, H.,Prinz, F.,Mengel, A.,Heinrich, T.,Balint, J.,Rengachari, S.,Irlbacher, H.,Stockigt, D.,Bomer, U.,Bader, B.,Gradl, S.N.,Nising, C.F.,von Nussbaum, F.,Mumberg, D.,Panne, D.,Wengner, A.M.; Discovery of BAY-985, a Highly Selective TBK1/IKK epsilon Inhibitor.; J.Med.Chem., 63:601-612, 2020; PubMed: 31859507; DOI: 10.1021/acs.jmedchem.9b01460

実験手法

X-RAY DIFFRACTION (3.15 Å)