6RSB

Structure based optimization of JAK1-ATP binding pocket Inhibitors in the aminopyrazole class

6RSB の概要

• エントリーDOI: 10.2210/pdb6rsb/pdb
• 分子名称: Tyrosine-protein kinase JAK1, 1-[(3~{R},4~{R})-4-(cyanomethyl)-1-[[4-(cyclohexen-1-yl)phenyl]methyl]-3-fluoranyl-piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide (3 entities in total)
• 機能のキーワード: inhibitor, complex, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70502.39

構造登録者

Brown, D.G.,Lupardus, P.J. (登録日: 2019-05-21, 公開日: 2020-07-08, 最終更新日: 2024-11-06)

• 主引用文献: Zak, M.,Gibbons, P.,Brown, D.G.; Structure based optimization of JAK1-ATP binding pocket Inhibitors in the aminopyrazole class; To Be Published,

実験手法

X-RAY DIFFRACTION (1.8 Å)