6RQ6

CYP121 in complex with 3-fluoro dicyclotyrosine

6RQ6 の概要

• エントリーDOI: 10.2210/pdb6rq6/pdb
• 分子名称: Mycocyclosin synthase, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, PROTOPORPHYRIN IX CONTAINING FE, ... (6 entities in total)
• 機能のキーワード: cyp121, p450, dicyclotyrosine derivatives, heme, oxidoreductase
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44942.24

構造登録者

Poddar, H.,Levy, C. (登録日: 2019-05-15, 公開日: 2020-04-22, 最終更新日: 2024-01-24)

• 主引用文献: Rajput, S.,McLean, K.J.,Poddar, H.,Selvam, I.R.,Nagalingam, G.,Triccas, J.A.,Levy, C.W.,Munro, A.W.,Hutton, C.A.; Structure-Activity Relationships of cyclo (l-Tyrosyl-l-tyrosine) Derivatives Binding to Mycobacterium tuberculosis CYP121: Iodinated Analogues Promote Shift to High-Spin Adduct.; J.Med.Chem., 62:9792-9805, 2019; PubMed: 31618032; DOI: 10.1021/acs.jmedchem.9b01199

実験手法

X-RAY DIFFRACTION (1.42 Å)