6RQ4

Inhibitor of ERK2

6RQ4 の概要

• エントリーDOI: 10.2210/pdb6rq4/pdb
• 分子名称: Mitogen-activated protein kinase 1, SULFATE ION, 6,6-dimethyl-2-[2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]-5-(2-morpholin-4-ylethyl)thieno[2,3-c]pyrrol-4-one, ... (4 entities in total)
• 機能のキーワード: protein kinase atp-binding site serine/threonine kinase, signaling protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43101.54

構造登録者

O'Reilly, M. (登録日: 2019-05-15, 公開日: 2019-12-04, 最終更新日: 2020-02-19)

• 主引用文献: Kidger, A.M.,Munck, J.M.,Saini, H.K.,Balmanno, K.,Minihane, E.,Courtin, A.,Graham, B.,O'Reilly, M.,Odle, R.,Cook, S.J.; Dual-Mechanism ERK1/2 Inhibitors Exploit a Distinct Binding Mode to Block Phosphorylation and Nuclear Accumulation of ERK1/2.; Mol.Cancer Ther., 19:525-539, 2020; PubMed: 31748345; DOI: 10.1158/1535-7163.MCT-19-0505

実験手法

X-RAY DIFFRACTION (1.96 Å)