6RKI

Fragment AZ-023 binding at the p53pT387/14-3-3 sigma interface

Summary for 6RKI

• Entry DOI: 10.2210/pdb6rki/pdb
• Descriptor: 14-3-3 protein sigma, Cellular tumor antigen p53, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: protein protein interaction, fragment soaking, stabilization, peptide binding protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 30052.50

Authors

Genet, S.,Wolter, M.,Guillory, X.,Somsen, B.,Leysen, S.,Castaldi, P.,Ottmann, C. (deposition date: 2019-04-30, release date: 2020-06-17, Last modification date: 2024-01-24)

• Primary citation: Guillory, X.,Wolter, M.,Leysen, S.,Neves, J.F.,Kuusk, A.,Genet, S.,Somsen, B.,Morrow, J.K.,Rivers, E.,van Beek, L.,Patel, J.,Goodnow, R.,Schoenherr, H.,Fuller, N.,Cao, Q.,Doveston, R.G.,Brunsveld, L.,Arkin, M.R.,Castaldi, P.,Boyd, H.,Landrieu, I.,Chen, H.,Ottmann, C.; Fragment-based Differential Targeting of PPI Stabilizer Interfaces.; J.Med.Chem., 63:6694-6707, 2020; PubMed: 32501690; DOI: 10.1021/acs.jmedchem.9b01942

Experimental method

X-RAY DIFFRACTION (1.88 Å)