6RJ2

Crystal structure of PHGDH in complex with compound 40

6RJ2 の概要

• エントリーDOI: 10.2210/pdb6rj2/pdb
• 分子名称: D-3-phosphoglycerate dehydrogenase, SULFATE ION, ~{N}-[(1~{R})-1-[4-(ethanoylsulfamoyl)phenyl]ethyl]-2-methyl-5-phenyl-pyrazole-3-carboxamide, ... (4 entities in total)
• 機能のキーワード: protein-ligand complex, dehydrogenase, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68210.57

構造登録者

Bader, G.,Wolkerstorfer, B.,Zoephel, A. (登録日: 2019-04-26, 公開日: 2019-08-07, 最終更新日: 2024-01-24)

• 主引用文献: Weinstabl, H.,Treu, M.,Rinnenthal, J.,Zahn, S.K.,Ettmayer, P.,Bader, G.,Dahmann, G.,Kessler, D.,Rumpel, K.,Mischerikow, N.,Savarese, F.,Gerstberger, T.,Mayer, M.,Zoephel, A.,Schnitzer, R.,Sommergruber, W.,Martinelli, P.,Arnhof, H.,Peric-Simov, B.,Hofbauer, K.S.,Garavel, G.,Scherbantin, Y.,Mitzner, S.,Fett, T.N.,Scholz, G.,Bruchhaus, J.,Burkard, M.,Kousek, R.,Ciftci, T.,Sharps, B.,Schrenk, A.,Harrer, C.,Haering, D.,Wolkerstorfer, B.,Zhang, X.,Lv, X.,Du, A.,Li, D.,Li, Y.,Quant, J.,Pearson, M.,McConnell, D.B.; Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) InhibitorBI-4924Disrupts Serine Biosynthesis.; J.Med.Chem., 62:7976-7997, 2019; PubMed: 31365252; DOI: 10.1021/acs.jmedchem.9b00718

実験手法

X-RAY DIFFRACTION (2 Å)