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6RIQ

MinCD filament from Pseudomonas aeruginosa

Summary for 6RIQ
Entry DOI10.2210/pdb6riq/pdb
EMDB information4897
DescriptorMinC, Site-determining protein, MAGNESIUM ION, ... (4 entities in total)
Functional Keywordsbacterial cell division, protein fibril
Biological sourcePseudomonas aeruginosa
More
Total number of polymer chains22
Total formula weight498782.92
Authors
Szewczak-Harris, A.,Wagstaff, J.,Lowe, J. (deposition date: 2019-04-24, release date: 2019-06-19, Last modification date: 2025-04-09)
Primary citationSzewczak-Harris, A.,Wagstaff, J.,Lowe, J.
Cryo-EM structure of the MinCD copolymeric filament from Pseudomonas aeruginosa at 3.1 angstrom resolution.
Febs Lett., 593:1915-1926, 2019
Cited by
PubMed Abstract: Positioning of the division site in many bacterial species relies on the MinCDE system, which prevents the cytokinetic Z-ring from assembling anywhere but the mid-cell, through an oscillatory diffusion-reaction mechanism. MinD dimers bind to membranes and, via their partner MinC, inhibit the polymerization of cell division protein FtsZ into the Z-ring. MinC and MinD form polymeric assemblies in solution and on cell membranes. Here, we report the high-resolution cryo-EM structure of the copolymeric filaments of Pseudomonas aeruginosa MinCD. The filaments consist of three protofilaments made of alternating MinC and MinD dimers. The MinCD protofilaments are almost completely straight and assemble as single protofilaments on lipid membranes, which we also visualized by cryo-EM.
PubMed: 31166018
DOI: 10.1002/1873-3468.13471
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (3.1 Å)
Structure validation

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数据于2025-07-02公开中

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