6R9W
Crystal structure of InhA in complex with AP-124 inhibitor
6R9W の概要
エントリーDOI | 10.2210/pdb6r9w/pdb |
分子名称 | Enoyl-[acyl-carrier-protein] reductase [NADH], (2~{S})-1-(benzimidazol-1-yl)-3-(2,3-dihydro-1~{H}-inden-5-yloxy)propan-2-ol, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (4 entities in total) |
機能のキーワード | inhibitor, complex, oxidoreductase, antibiotic resistance |
由来する生物種 | Mycobacterium tuberculosis H37Rv |
タンパク質・核酸の鎖数 | 6 |
化学式量合計 | 177311.27 |
構造登録者 | |
主引用文献 | Kamsri, P.,Hanwarinroj, C.,Phusi, N.,Pornprom, T.,Chayajarus, K.,Punkvang, A.,Suttipanta, N.,Srimanote, P.,Suttisintong, K.,Songsiriritthigul, C.,Saparpakorn, P.,Hannongbua, S.,Rattanabunyong, S.,Seetaha, S.,Choowongkomon, K.,Sureram, S.,Kittakoop, P.,Hongmanee, P.,Santanirand, P.,Chen, Z.,Zhu, W.,Blood, R.A.,Takebayashi, Y.,Hinchliffe, P.,Mulholland, A.J.,Spencer, J.,Pungpo, P. Discovery of New and Potent InhA Inhibitors as Antituberculosis Agents: Structure-Based Virtual Screening Validated by Biological Assays and X-ray Crystallography. J.Chem.Inf.Model., 60:226-234, 2020 Cited by PubMed: 31820972DOI: 10.1021/acs.jcim.9b00918 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.75 Å) |
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