6R8R
Structure of the Wnt deacylase Notum in complex with isoquinoline 45
6R8R の概要
エントリーDOI | 10.2210/pdb6r8r/pdb |
分子名称 | Palmitoleoyl-protein carboxylesterase NOTUM, 2-acetamido-2-deoxy-beta-D-glucopyranose, ~{N}-isoquinolin-6-yl-2-(2-methylphenoxy)ethanamide, ... (7 entities in total) |
機能のキーワード | wnt signalling, notum inhibitor, crystallographic fragment screen, hydrolase |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 45860.54 |
構造登録者 | |
主引用文献 | Atkinson, B.N.,Steadman, D.,Zhao, Y.,Sipthorp, J.,Vecchia, L.,Ruza, R.R.,Jeganathan, F.,Lines, G.,Frew, S.,Monaghan, A.,Kjær, S.,Bictash, M.,Jones, E.Y.,Fish, P.V. Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen. Medchemcomm, 10:1361-1369, 2019 Cited by PubMed: 31534655DOI: 10.1039/c9md00096h 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.27 Å) |
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