6R8Q

STRUCTURE OF THE WNT DEACYLASE NOTUM IN COMPLEX WITH A BENZOTRIAZOLE FRAGMENT

Summary for 6R8Q

Entry DOI	10.2210/pdb6r8q/pdb
Descriptor	Palmitoleoyl-protein carboxylesterase NOTUM, 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... (6 entities in total)
Functional Keywords	wnt signalling, notum inhibitor, crystallographic fragment screen, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	45149.50
Authors	Ruza, R.R.,Vecchia, L.,Jones, E.Y. (deposition date: 2019-04-02, release date: 2019-05-08, Last modification date: 2024-01-24)
Primary citation	Atkinson, B.N.,Steadman, D.,Zhao, Y.,Sipthorp, J.,Vecchia, L.,Ruza, R.R.,Jeganathan, F.,Lines, G.,Frew, S.,Monaghan, A.,Kjær, S.,Bictash, M.,Jones, E.Y.,Fish, P.V. Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen. Medchemcomm, 10:1361-1369, 2019 Cited by PubMed: 31534655 DOI: 10.1039/c9md00096h PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation