6R8Q

STRUCTURE OF THE WNT DEACYLASE NOTUM IN COMPLEX WITH A BENZOTRIAZOLE FRAGMENT

6R8Q の概要

• エントリーDOI: 10.2210/pdb6r8q/pdb
• 分子名称: Palmitoleoyl-protein carboxylesterase NOTUM, 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... (6 entities in total)
• 機能のキーワード: wnt signalling, notum inhibitor, crystallographic fragment screen, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 45149.50

構造登録者

Ruza, R.R.,Vecchia, L.,Jones, E.Y. (登録日: 2019-04-02, 公開日: 2019-05-08, 最終更新日: 2024-01-24)

• 主引用文献: Atkinson, B.N.,Steadman, D.,Zhao, Y.,Sipthorp, J.,Vecchia, L.,Ruza, R.R.,Jeganathan, F.,Lines, G.,Frew, S.,Monaghan, A.,Kjær, S.,Bictash, M.,Jones, E.Y.,Fish, P.V.; Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen.; Medchemcomm, 10:1361-1369, 2019; PubMed: 31534655; DOI: 10.1039/c9md00096h

実験手法

X-RAY DIFFRACTION (1.5 Å)