6R6Y
Crystal structure of human carbonic anhydrase isozyme XII with 4-chloro-2-cyclohexylsulfanyl-N-(2-hydroxyethyl)-5-sulfamoyl-benzamide
Summary for 6R6Y
| Entry DOI | 10.2210/pdb6r6y/pdb |
| Descriptor | Carbonic anhydrase 12, ZINC ION, 1,2-ETHANEDIOL, ... (6 entities in total) |
| Functional Keywords | drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor complex, lyase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 4 |
| Total formula weight | 122155.40 |
| Authors | Smirnov, A.,Manakova, E.,Grazulis, S. (deposition date: 2019-03-28, release date: 2020-04-08, Last modification date: 2024-01-24) |
| Primary citation | Zaksauskas, A.,Capkauskaite, E.,Jezepcikas, L.,Linkuviene, V.,Paketuryte, V.,Smirnov, A.,Leitans, J.,Kazaks, A.,Dvinskis, E.,Manakova, E.,Grazulis, S.,Tars, K.,Matulis, D. Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms. Eur.J.Med.Chem., 185:111825-111825, 2020 Cited by PubMed: 31740053DOI: 10.1016/j.ejmech.2019.111825 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.38 Å) |
Structure validation
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