6R4C

Aurora-A in complex with shape-diverse fragment 57

Summary for 6R4C

Entry DOI	10.2210/pdb6r4c/pdb
Descriptor	Aurora kinase A, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	ser/thr protein kinase allosteric site, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	33837.16
Authors	Bayliss, R.,McIntyre, P.J. (deposition date: 2019-03-22, release date: 2019-05-01, Last modification date: 2019-07-10)
Primary citation	Zhang, R.,McIntyre, P.J.,Collins, P.M.,Foley, D.J.,Arter, C.,von Delft, F.,Bayliss, R.,Warriner, S.,Nelson, A. Construction of a Shape-Diverse Fragment Set: Design, Synthesis and Screen against Aurora-A Kinase. Chemistry, 25:6831-6839, 2019 Cited by PubMed: 31026091 DOI: 10.1002/chem.201900815 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.04 Å)

Structure validation