6QYO

Structure of MBP-Mcl-1 in complex with compound 18a

6QYO の概要

• エントリーDOI: 10.2210/pdb6qyo/pdb
• 関連するPDBエントリー: 6QXJ 6qyk 6qyl 6qyn
• 関連するBIRD辞書のPRD_ID: PRD_900001
• 分子名称: Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, (2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-ethyl-thieno[2,3-d]pyrimidin-4-yl]oxy-3-phenyl-propanoic acid, ... (4 entities in total)
• 機能のキーワード: apoptosis-inhibitor complex, mcl1, small molecule inhibitor, mbp, apoptosis
• 由来する生物種: Escherichia coli; 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 58163.32

構造登録者

Dokurno, P.,Szlavik, Z.,Ondi, L.,Csekei, M.,Paczal, A.,Szabo, Z.B.,Radics, G.,Murray, J.,Davidson, J.,Chen, I.,Davis, B.,Hubbard, R.E.,Pedder, C.,Surgenor, A.E.,Smith, J.,Robertson, A.,LeToumelin-Braizat, G.,Cauquil, N.,Zarka, M.,Demarles, D.,Perron-Sierra, F.,Geneste, O.,Kotschy, A. (登録日: 2019-03-09, 公開日: 2019-08-07, 最終更新日: 2024-01-24)

• 主引用文献: Szlavik, Z.,Ondi, L.,Csekei, M.,Paczal, A.,Szabo, Z.B.,Radics, G.,Murray, J.,Davidson, J.,Chen, I.,Davis, B.,Hubbard, R.E.,Pedder, C.,Dokurno, P.,Surgenor, A.,Smith, J.,Robertson, A.,LeToumelin-Braizat, G.,Cauquil, N.,Zarka, M.,Demarles, D.,Perron-Sierra, F.,Claperon, A.,Colland, F.,Geneste, O.,Kotschy, A.; Structure-Guided Discovery of a Selective Mcl-1 Inhibitor with Cellular Activity.; J.Med.Chem., 62:6913-6924, 2019; PubMed: 31339316; DOI: 10.1021/acs.jmedchem.9b00134

実験手法

X-RAY DIFFRACTION (2.1 Å)