6QTG

Crystal structure of human CDK8/CYCC in complex with BI-1347

Summary for 6QTG

Entry DOI	10.2210/pdb6qtg/pdb
Descriptor	Cyclin-dependent kinase 8, Cyclin-C, 2-[4-(4-isoquinolin-4-ylphenyl)pyrazol-1-yl]-~{N},~{N}-dimethyl-ethanamide, ... (4 entities in total)
Functional Keywords	inhibitor, complex, cell cycle
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	80670.91
Authors	Boettcher, J. (deposition date: 2019-02-25, release date: 2020-03-18, Last modification date: 2024-01-24)
Primary citation	Hofmann, M.H.,Mani, R.,Engelhardt, H.,Impagnatiello, M.A.,Carotta, S.,Kerenyi, M.,Lorenzo-Herrero, S.,Bottcher, J.,Scharn, D.,Arnhof, H.,Zoephel, A.,Schnitzer, R.,Gerstberger, T.,Sanderson, M.P.,Rajgolikar, G.,Goswami, S.,Vasu, S.,Ettmayer, P.,Gonzalez, S.,Pearson, M.,McConnell, D.B.,Kraut, N.,Muthusamy, N.,Moll, J. Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance. Mol.Cancer Ther., 19:1018-1030, 2020 Cited by PubMed: 32024684 DOI: 10.1158/1535-7163.MCT-19-0789 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation