6QTG
Crystal structure of human CDK8/CYCC in complex with BI-1347
Summary for 6QTG
Entry DOI | 10.2210/pdb6qtg/pdb |
Descriptor | Cyclin-dependent kinase 8, Cyclin-C, 2-[4-(4-isoquinolin-4-ylphenyl)pyrazol-1-yl]-~{N},~{N}-dimethyl-ethanamide, ... (4 entities in total) |
Functional Keywords | inhibitor, complex, cell cycle |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 80670.91 |
Authors | Boettcher, J. (deposition date: 2019-02-25, release date: 2020-03-18, Last modification date: 2024-01-24) |
Primary citation | Hofmann, M.H.,Mani, R.,Engelhardt, H.,Impagnatiello, M.A.,Carotta, S.,Kerenyi, M.,Lorenzo-Herrero, S.,Bottcher, J.,Scharn, D.,Arnhof, H.,Zoephel, A.,Schnitzer, R.,Gerstberger, T.,Sanderson, M.P.,Rajgolikar, G.,Goswami, S.,Vasu, S.,Ettmayer, P.,Gonzalez, S.,Pearson, M.,McConnell, D.B.,Kraut, N.,Muthusamy, N.,Moll, J. Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance. Mol.Cancer Ther., 19:1018-1030, 2020 Cited by PubMed: 32024684DOI: 10.1158/1535-7163.MCT-19-0789 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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