6QTG

Crystal structure of human CDK8/CYCC in complex with BI-1347

6QTG の概要

• エントリーDOI: 10.2210/pdb6qtg/pdb
• 分子名称: Cyclin-dependent kinase 8, Cyclin-C, 2-[4-(4-isoquinolin-4-ylphenyl)pyrazol-1-yl]-~{N},~{N}-dimethyl-ethanamide, ... (4 entities in total)
• 機能のキーワード: inhibitor, complex, cell cycle
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 80670.91

構造登録者

Boettcher, J. (登録日: 2019-02-25, 公開日: 2020-03-18, 最終更新日: 2024-01-24)

• 主引用文献: Hofmann, M.H.,Mani, R.,Engelhardt, H.,Impagnatiello, M.A.,Carotta, S.,Kerenyi, M.,Lorenzo-Herrero, S.,Bottcher, J.,Scharn, D.,Arnhof, H.,Zoephel, A.,Schnitzer, R.,Gerstberger, T.,Sanderson, M.P.,Rajgolikar, G.,Goswami, S.,Vasu, S.,Ettmayer, P.,Gonzalez, S.,Pearson, M.,McConnell, D.B.,Kraut, N.,Muthusamy, N.,Moll, J.; Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance.; Mol.Cancer Ther., 19:1018-1030, 2020; PubMed: 32024684; DOI: 10.1158/1535-7163.MCT-19-0789

実験手法

X-RAY DIFFRACTION (2.7 Å)