6QRL

Crystal structure of ShkA _Rec1 in complex with c-di-GMP

6QRL の概要

• エントリーDOI: 10.2210/pdb6qrl/pdb
• 分子名称: Hybrid kinase, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), SULFATE ION, ... (4 entities in total)
• 機能のキーワード: cyclic di-gmp, pseudo receiver domain, second messenger, hybride histidine kinase, shka, auto-inhibition, signaling protein
• 由来する生物種: Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 29429.89

構造登録者

Dubey, B.N.,Schirmer, T. (登録日: 2019-02-19, 公開日: 2020-01-08, 最終更新日: 2024-01-24)

• 主引用文献: Dubey, B.N.,Agustoni, E.,Bohm, R.,Kaczmarczyk, A.,Mangia, F.,von Arx, C.,Jenal, U.,Hiller, S.,Plaza-Menacho, I.,Schirmer, T.; Hybrid histidine kinase activation by cyclic di-GMP-mediated domain liberation.; Proc.Natl.Acad.Sci.USA, 117:1000-1008, 2020; PubMed: 31882446; DOI: 10.1073/pnas.1911427117

実験手法

X-RAY DIFFRACTION (1.84 Å)