6QR7

Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with inhibitor

6QR7 の概要

• エントリーDOI: 10.2210/pdb6qr7/pdb
• 関連するPDBエントリー: 6NVR
• 分子名称: tRNA (guanine-N(1)-)-methyltransferase, 5-azanyl-3-[1-[[4-(piperidin-1-ylmethyl)phenyl]methyl]indol-6-yl]-1~{H}-pyrazole-4-carbonitrile (3 entities in total)
• 機能のキーワード: trmd, trna methyltransferase, spout methyltransferase, transferase
• 由来する生物種: Mycobacterium abscessus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 53690.37

構造登録者

Thomas, S.E.,Whitehouse, A.J.,Coyne, A.G.,Abell, C.,Mendes, V.,Blundell, T.L. (登録日: 2019-02-19, 公開日: 2019-09-18, 最終更新日: 2024-01-24)

• 主引用文献: Whitehouse, A.J.,Thomas, S.E.,Brown, K.P.,Fanourakis, A.,Chan, D.S.,Libardo, M.D.J.,Mendes, V.,Boshoff, H.I.M.,Floto, R.A.,Abell, C.,Blundell, T.L.,Coyne, A.G.; Development of Inhibitors againstMycobacterium abscessustRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches.; J.Med.Chem., 62:7210-7232, 2019; PubMed: 31282680; DOI: 10.1021/acs.jmedchem.9b00809

実験手法

X-RAY DIFFRACTION (2.03 Å)