6QPL

Crystal structure of Spindlin1 in complex with the inhibitor MS31

6QPL の概要

分子名称Spindlin-1, (4S)-2-METHYL-2,4-PENTANEDIOL, DIMETHYL SULFOXIDE, ... (8 entities in total)
機能のキーワードepigenetics, tudor domain, methyl-lysine, methyl-arginine, cell cycle
由来する生物種Homo sapiens (Human)
ポリマー鎖数1
分子量合計26495.97
構造登録者
Johansson, C.,Krojer, T.,Xiong, Y.,Jin, J.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.,Oppermann, U.C.T. (登録日: 2019-02-14, 公開日: 2019-07-17, 最終更新日: 2019-11-06)
主引用文献
Xiong, Y.,Greschik, H.,Johansson, C.,Seifert, L.,Bacher, J.,Park, K.S.,Babault, N.,Martini, M.,Fagan, V.,Li, F.,Chau, I.,Christott, T.,Dilworth, D.,Barsyte-Lovejoy, D.,Vedadi, M.,Arrowsmith, C.H.,Brennan, P.,Fedorov, O.,Jung, M.,Farnie, G.,Liu, J.,Oppermann, U.,Schule, R.,Jin, J.
Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1).
J.Med.Chem., 62:8996-9007, 2019
PubMed: 31260300 (主引用文献が同じPDBエントリー)
DOI: 10.1021/acs.jmedchem.9b00522
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (1.6 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.20830 1.2% 8.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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