6QPL

Crystal structure of Spindlin1 in complex with the inhibitor MS31

6QPL の概要

• エントリーDOI: 10.2210/pdb6qpl/pdb
• 分子名称: Spindlin-1, (4S)-2-METHYL-2,4-PENTANEDIOL, DIMETHYL SULFOXIDE, ... (8 entities in total)
• 機能のキーワード: epigenetics, tudor domain, methyl-lysine, methyl-arginine, cell cycle
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26495.97

構造登録者

Johansson, C.,Krojer, T.,Xiong, Y.,Jin, J.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.,Oppermann, U.C.T. (登録日: 2019-02-14, 公開日: 2019-07-17, 最終更新日: 2024-01-24)

• 主引用文献: Xiong, Y.,Greschik, H.,Johansson, C.,Seifert, L.,Bacher, J.,Park, K.S.,Babault, N.,Martini, M.,Fagan, V.,Li, F.,Chau, I.,Christott, T.,Dilworth, D.,Barsyte-Lovejoy, D.,Vedadi, M.,Arrowsmith, C.H.,Brennan, P.,Fedorov, O.,Jung, M.,Farnie, G.,Liu, J.,Oppermann, U.,Schule, R.,Jin, J.; Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1).; J.Med.Chem., 62:8996-9007, 2019; PubMed: 31260300; DOI: 10.1021/acs.jmedchem.9b00522

実験手法

X-RAY DIFFRACTION (1.6 Å)