6QP1

Crystal structure of the PLP-bound C-S lyase in the external aldimine form from Staphylococcus hominis complexed with an inhibitor, L-cycloserine.

Summary for 6QP1

Entry DOI	10.2210/pdb6qp1/pdb
Related	6QP2 6QP3 6RVI 6RVJ
Descriptor	Aminotransferase, [5-hydroxy-6-methyl-4-({[(4E)-3-oxo-1,2-oxazolidin-4-ylidene]amino}methyl)pyridin-3-yl]methyl dihydrogen phosphate (3 entities in total)
Functional Keywords	pyridoxal phosphate binding, cystathionine beta-lyase, lyase, inhibitor, complex, l-cycloserine, external aldimine
Biological source	Staphylococcus hominis
Total number of polymer chains	2
Total formula weight	97519.74
Authors	Herman, R.,Rudden, M.,Wilkinson, A.J.,Hanai, S.,Thomas, G.H. (deposition date: 2019-02-13, release date: 2020-03-04, Last modification date: 2024-01-24)
Primary citation	Rudden, M.,Herman, R.,Rose, M.,Bawdon, D.,Cox, D.S.,Dodson, E.,Holden, M.T.G.,Wilkinson, A.J.,James, A.G.,Thomas, G.H. The molecular basis of thioalcohol production in human body odour. Sci Rep, 10:12500-12500, 2020 Cited by PubMed: 32719469 DOI: 10.1038/s41598-020-68860-z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.42 Å)

Structure validation