6QNL
Three dimensional structure of human carbonic anhydrase XII in complex with benzenesulfonamide
Summary for 6QNL
Entry DOI | 10.2210/pdb6qnl/pdb |
Descriptor | Carbonic anhydrase 12, ZINC ION, methyl 4-[(4-chloranyl-2-cyclohexylsulfanyl-5-sulfamoyl-phenyl)carbonylamino]butanoate, ... (4 entities in total) |
Functional Keywords | lyase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 121486.38 |
Authors | Dvinskis, E.,Leitans, J.,Tars, K. (deposition date: 2019-02-11, release date: 2020-03-04, Last modification date: 2021-10-06) |
Primary citation | Zaksauskas, A.,Capkauskaite, E.,Jezepcikas, L.,Linkuviene, V.,Paketuryte, V.,Smirnov, A.,Leitans, J.,Kazaks, A.,Dvinskis, E.,Manakova, E.,Grazulis, S.,Tars, K.,Matulis, D. Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms. Eur.J.Med.Chem., 185:111825-111825, 2020 Cited by PubMed: 31740053DOI: 10.1016/j.ejmech.2019.111825 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.53 Å) |
Structure validation
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