6QNL

Three dimensional structure of human carbonic anhydrase XII in complex with benzenesulfonamide

Summary for 6QNL

Entry DOI	10.2210/pdb6qnl/pdb
Descriptor	Carbonic anhydrase 12, ZINC ION, methyl 4-[(4-chloranyl-2-cyclohexylsulfanyl-5-sulfamoyl-phenyl)carbonylamino]butanoate, ... (4 entities in total)
Functional Keywords	lyase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	121486.38
Authors	Dvinskis, E.,Leitans, J.,Tars, K. (deposition date: 2019-02-11, release date: 2020-03-04, Last modification date: 2021-10-06)
Primary citation	Zaksauskas, A.,Capkauskaite, E.,Jezepcikas, L.,Linkuviene, V.,Paketuryte, V.,Smirnov, A.,Leitans, J.,Kazaks, A.,Dvinskis, E.,Manakova, E.,Grazulis, S.,Tars, K.,Matulis, D. Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms. Eur.J.Med.Chem., 185:111825-111825, 2020 Cited by PubMed: 31740053 DOI: 10.1016/j.ejmech.2019.111825 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.53 Å)

Structure validation