Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6QMJ

Small molecule inhibitor of the KEAP1-NRF2 protein-protein interaction

Summary for 6QMJ
Entry DOI10.2210/pdb6qmj/pdb
DescriptorKelch-like ECH-associated protein 1, SULFATE ION, CHLORIDE ION, ... (5 entities in total)
Functional Keywordsprotein ubiquitination, oxidative stress, kelch motif, protein binding
Biological sourceMus musculus (Mouse)
Total number of polymer chains1
Total formula weight35891.48
Authors
Davies, T.G. (deposition date: 2019-02-07, release date: 2019-04-24, Last modification date: 2019-05-22)
Primary citationHeightman, T.D.,Callahan, J.F.,Chiarparin, E.,Coyle, J.E.,Griffiths-Jones, C.,Lakdawala, A.S.,McMenamin, R.,Mortenson, P.N.,Norton, D.,Peakman, T.M.,Rich, S.J.,Richardson, C.,Rumsey, W.L.,Sanchez, Y.,Saxty, G.,Willems, H.M.G.,Wolfe 3rd, L.,Woolford, A.J.,Wu, Z.,Yan, H.,Kerns, J.K.,Davies, T.G.
Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein-Protein Interaction.
J.Med.Chem., 62:4683-4702, 2019
Cited by
PubMed: 30973731
DOI: 10.1021/acs.jmedchem.9b00279
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.86 Å)
Structure validation

218500

건을2024-04-17부터공개중

PDB statisticsPDBj update infoContact PDBjnumon