6QM8

Leishmania tarentolae proteasome 20S subunit apo structure

6QM8 の概要

EMDBエントリー4591
分子名称Proteasome alpha1 chain, Proteasome alpha2 chain, Proteasome alpha3 chain, ... (14 entities in total)
機能のキーワードproteasome 20s subunit, hydrolase
由来する生物種Leishmania tarentolae
ポリマー鎖数28
分子量合計847844.5
構造登録者
Rowland, P.,Goswami, P. (登録日: 2019-02-01, 公開日: 2019-04-17, 最終更新日: 2019-05-22)
主引用文献
Wyllie, S.,Brand, S.,Thomas, M.,De Rycker, M.,Chung, C.W.,Pena, I.,Bingham, R.P.,Bueren-Calabuig, J.A.,Cantizani, J.,Cebrian, D.,Craggs, P.D.,Ferguson, L.,Goswami, P.,Hobrath, J.,Howe, J.,Jeacock, L.,Ko, E.J.,Korczynska, J.,MacLean, L.,Manthri, S.,Martinez, M.S.,Mata-Cantero, L.,Moniz, S.,Nuhs, A.,Osuna-Cabello, M.,Pinto, E.,Riley, J.,Robinson, S.,Rowland, P.,Simeons, F.R.C.,Shishikura, Y.,Spinks, D.,Stojanovski, L.,Thomas, J.,Thompson, S.,Viayna Gaza, E.,Wall, R.J.,Zuccotto, F.,Horn, D.,Ferguson, M.A.J.,Fairlamb, A.H.,Fiandor, J.M.,Martin, J.,Gray, D.W.,Miles, T.J.,Gilbert, I.H.,Read, K.D.,Marco, M.,Wyatt, P.G.
Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.
Proc.Natl.Acad.Sci.USA, 116:9318-9323, 2019
PubMed: 30962368 (主引用文献が同じPDBエントリー)
DOI: 10.1073/pnas.1820175116
MImport into Mendeley
実験手法
ELECTRON MICROSCOPY (3.3 Å)
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構造検証レポート

ClashscoreRamachandran outliersSidechain outliers4 0.9% 10.1%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
検証レポート(詳細版)をダウンロード

他の静止画像(非対称単位)

Molmil generated image of 6qm8
回転なし
Molmil generated image of 6qm8
x軸(左右方向)周りに90°回転
Molmil generated image of 6qm8
y軸(上下方向)周りに90°回転