6QL1

Crystal structure of chimeric carbonic anhydrase VI with 4-[(4,6-dimethylpyrimidin-2-yl)thio]-2,3,5,6-tetrafluorobenzenesulfonamide

Summary for 6QL1

Entry DOI	10.2210/pdb6ql1/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, DIMETHYL SULFOXIDE, ... (8 entities in total)
Functional Keywords	drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor complex, lyase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	30492.51
Authors	Smirnov, A.,Manakova, E.,Grazulis, S. (deposition date: 2019-01-31, release date: 2019-09-25, Last modification date: 2024-01-24)
Primary citation	Kazokaite, J.,Kairys, V.,Smirnoviene, J.,Smirnov, A.,Manakova, E.,Tolvanen, M.,Parkkila, S.,Matulis, D. Engineered Carbonic Anhydrase VI-Mimic Enzyme Switched the Structure and Affinities of Inhibitors. Sci Rep, 9:12710-12710, 2019 Cited by PubMed: 31481705 DOI: 10.1038/s41598-019-49094-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.42 Å)

Structure validation