6QJ5

X-ray structure of PPARgamma LBD with the ligand NV1380

Summary for 6QJ5

Entry DOI	10.2210/pdb6qj5/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, (2~{S})-3-methyl-2-[(4-octoxyphenyl)carbonylamino]butanoic acid (3 entities in total)
Functional Keywords	bundle of alpha-helices and small four-stranded beta-sheet, transcription factor, dna-binding, diabetes type ii, dna binding protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	69515.28
Authors	Pochetti, G.,Montanari, R.,Capelli, D. (deposition date: 2019-01-22, release date: 2020-02-05, Last modification date: 2024-01-24)
Primary citation	Peiretti, F.,Montanari, R.,Capelli, D.,Bonardo, B.,Colson, C.,Amri, E.Z.,Grimaldi, M.,Balaguer, P.,Ito, K.,Roeder, R.G.,Pochetti, G.,Brunel, J.M. A Novel N-Substituted Valine Derivative with Unique Peroxisome Proliferator-Activated Receptor gamma Binding Properties and Biological Activities. J.Med.Chem., 63:13124-13139, 2020 Cited by PubMed: 33142057 DOI: 10.1021/acs.jmedchem.0c01555 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation