6QJ5

X-ray structure of PPARgamma LBD with the ligand NV1380

6QJ5 の概要

• エントリーDOI: 10.2210/pdb6qj5/pdb
• 分子名称: Peroxisome proliferator-activated receptor gamma, (2~{S})-3-methyl-2-[(4-octoxyphenyl)carbonylamino]butanoic acid (3 entities in total)
• 機能のキーワード: bundle of alpha-helices and small four-stranded beta-sheet, transcription factor, dna-binding, diabetes type ii, dna binding protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 69515.28

構造登録者

Pochetti, G.,Montanari, R.,Capelli, D. (登録日: 2019-01-22, 公開日: 2020-02-05, 最終更新日: 2024-01-24)

• 主引用文献: Peiretti, F.,Montanari, R.,Capelli, D.,Bonardo, B.,Colson, C.,Amri, E.Z.,Grimaldi, M.,Balaguer, P.,Ito, K.,Roeder, R.G.,Pochetti, G.,Brunel, J.M.; A Novel N-Substituted Valine Derivative with Unique Peroxisome Proliferator-Activated Receptor gamma Binding Properties and Biological Activities.; J.Med.Chem., 63:13124-13139, 2020; PubMed: 33142057; DOI: 10.1021/acs.jmedchem.0c01555

実験手法

X-RAY DIFFRACTION (2 Å)