6QHB

Crystal Structure of Human Kallikrein 6 in complex with GSK578724A

Summary for 6QHB

• Entry DOI: 10.2210/pdb6qhb/pdb
• Descriptor: Kallikrein-6, ~{N}-(4-carbamimidoylphenyl)-3-methoxy-2-oxidanyl-benzamide, GLYCEROL, ... (4 entities in total)
• Functional Keywords: protease, inhibitor, complex, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 49498.08

Authors

Thorpe, J.H. (deposition date: 2019-01-16, release date: 2019-02-06, Last modification date: 2024-01-24)

• Primary citation: White, G.V.,Edgar, E.V.,Holmes, D.S.,Lewell, X.Q.,Liddle, J.,Polyakova, O.,Smith, K.J.,Thorpe, J.H.,Walker, A.L.,Wang, Y.,Young, R.J.,Hovnanian, A.; Kallikrein 5 inhibitors identified through structure based drug design in search for a treatment for Netherton Syndrome.; Bioorg. Med. Chem. Lett., 29:821-825, 2019; PubMed: 30691925; DOI: 10.1016/j.bmcl.2019.01.020

Experimental method

X-RAY DIFFRACTION (1.84 Å)