6QGD

Structure of human Mcl-1 in complex with thienopyrimidine inhibitor

6QGD の概要

• エントリーDOI: 10.2210/pdb6qgd/pdb
• 関連するPDBエントリー: 6qfi 6qfm 6qfq
• 関連するBIRD辞書のPRD_ID: PRD_900001
• 分子名称: Maltose-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, 2-[(6-ethyl-5-phenyl-thieno[2,3-d]pyrimidin-4-yl)amino]-3-oxidanyl-propanoic acid, ... (5 entities in total)
• 機能のキーワード: apoptosis, mcl1, mbp, small molecule inhibitor
• 由来する生物種: Escherichia coli O157:H7; 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 57934.55

構造登録者

Dokurno, P.,Murray, J.,Davidson, J.,Chen, I.,Davis, B.,Graham, C.J.,Harris, R.,Jordan, A.M.,Matassova, N.,Pedder, C.,Ray, S.,Roughley, S.,Smith, J.,Walmsley, C.,Wang, Y.,Whitehead, N.,Williamson, D.S.,Casara, P.,Le Diguarher, T.,Hickman, J.,Stark, J.,Kotschy, A.,Geneste, O.,Hubbard, R.E. (登録日: 2019-01-11, 公開日: 2019-06-12, 最終更新日: 2024-01-24)

• 主引用文献: Murray, J.B.,Davidson, J.,Chen, I.,Davis, B.,Dokurno, P.,Graham, C.J.,Harris, R.,Jordan, A.,Matassova, N.,Pedder, C.,Ray, S.,Roughley, S.D.,Smith, J.,Walmsley, C.,Wang, Y.,Whitehead, N.,Williamson, D.S.,Casara, P.,Le Diguarher, T.,Hickman, J.,Stark, J.,Kotschy, A.,Geneste, O.,Hubbard, R.E.; Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1.; Acs Omega, 4:8892-8906, 2019; PubMed: 31459977; DOI: 10.1021/acsomega.9b00611

実験手法

X-RAY DIFFRACTION (1.8 Å)