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6QG7

Structure of the mitogen activated kinase kinase 7 in complex with pyrazolopyrimidine 1k

Summary for 6QG7
Entry DOI10.2210/pdb6qg7/pdb
Related6QFL 6QFR 6QFT 6QG4
DescriptorDual specificity mitogen-activated protein kinase kinase 7, (R)-1-(3-(4-amino-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (3 entities in total)
Functional Keywordsprotein kinase, kinase, mkk7, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight36545.32
Authors
Wolle, P.,Mueller, M.P.,Rauh, D. (deposition date: 2019-01-10, release date: 2019-05-22, Last modification date: 2019-06-26)
Primary citationWolle, P.,Engel, J.,Smith, S.,Goebel, L.,Hennes, E.,Lategahn, J.,Rauh, D.
Characterization of Covalent Pyrazolopyrimidine-MKK7 Complexes and a Report on a Unique DFG-in/Leu-in Conformation of Mitogen-Activated Protein Kinase Kinase 7 (MKK7).
J.Med.Chem., 62:5541-5546, 2019
Cited by
PubMed: 31083997
DOI: 10.1021/acs.jmedchem.9b00472
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

217705

数据于2024-03-27公开中

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