6QFT
Structure of the mitogen activated kinase kinase 7 in complex with pyrazolopyrimidin 1b
Summary for 6QFT
Entry DOI | 10.2210/pdb6qft/pdb |
Related | 6QFL 6QFR |
Descriptor | Dual specificity mitogen-activated protein kinase kinase 7, 1-[(3~{R})-3-(4-azanyl-3-iodanyl-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl]propan-1-one (3 entities in total) |
Functional Keywords | protein kinase, kinase, mkk7, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 36547.08 |
Authors | Wolle, P.,Mueller, M.P.,Rauh, D. (deposition date: 2019-01-10, release date: 2019-05-22, Last modification date: 2024-01-24) |
Primary citation | Wolle, P.,Engel, J.,Smith, S.,Goebel, L.,Hennes, E.,Lategahn, J.,Rauh, D. Characterization of Covalent Pyrazolopyrimidine-MKK7 Complexes and a Report on a Unique DFG-in/Leu-in Conformation of Mitogen-Activated Protein Kinase Kinase 7 (MKK7). J.Med.Chem., 62:5541-5546, 2019 Cited by PubMed: 31083997DOI: 10.1021/acs.jmedchem.9b00472 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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