6QFT

Structure of the mitogen activated kinase kinase 7 in complex with pyrazolopyrimidin 1b

6QFT の概要

関連するPDBエントリー6QFL 6QFR
分子名称Dual specificity mitogen-activated protein kinase kinase 7, 1-[(3~{R})-3-(4-azanyl-3-iodanyl-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl]propan-1-one (3 entities in total)
機能のキーワードprotein kinase, kinase, mkk7, transferase
由来する生物種Homo sapiens (Human)
ポリマー鎖数1
分子量合計36547.08
構造登録者
Wolle, P.,Mueller, M.P.,Rauh, D. (登録日: 2019-01-10, 公開日: 2019-05-22, 最終更新日: 2019-06-12)
主引用文献
Wolle, P.,Engel, J.,Smith, S.,Goebel, L.,Hennes, E.,Lategahn, J.,Rauh, D.
Characterization of Covalent Pyrazolopyrimidine-MKK7 Complexes and a Report on a Unique DFG-in/Leu-in Conformation of Mitogen-Activated Protein Kinase Kinase 7 (MKK7).
J.Med.Chem., 2019
PubMed: 31083997 (主引用文献が同じPDBエントリー)
DOI: 10.1021/acs.jmedchem.9b00472
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.7 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.281300 0.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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