6QFE

Crystal Structure of Human Kallikrein 5 in complex with GSK144

Summary for 6QFE

Entry DOI	10.2210/pdb6qfe/pdb
Descriptor	Kallikrein-5, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	protease, inhibitor, complex, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	52519.96
Authors	Thorpe, J.H. (deposition date: 2019-01-10, release date: 2019-05-08, Last modification date: 2024-01-24)
Primary citation	Thorpe, J.H.,Edgar, E.V.,Smith, K.J.,Lewell, X.Q.,Rella, M.,White, G.V.,Polyakova, O.,Nassau, P.,Walker, A.L.,Holmes, D.S.,Pearce, A.C.,Wang, Y.,Liddle, J.,Hovnanian, A. Evaluation of a crystallographic surrogate for kallikrein 5 in the discovery of novel inhibitors for Netherton syndrome. Acta Crystallogr.,Sect.F, 75:385-391, 2019 Cited by PubMed: 31045568 DOI: 10.1107/S2053230X19003169 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.67 Å)

Structure validation