6QFE

Crystal Structure of Human Kallikrein 5 in complex with GSK144

6QFE の概要

分子名称Kallikrein-5, N-ACETYL-D-GLUCOSAMINE, SODIUM ION, ... (5 entities in total)
機能のキーワードprotease, inhibitor, complex, hydrolase
由来する生物種Homo sapiens (Human)
ポリマー鎖数2
分子量合計52555.99
構造登録者
Thorpe, J.H. (登録日: 2019-01-10, 公開日: 2019-05-08, 最終更新日: 2019-05-15)
主引用文献
Thorpe, J.H.,Edgar, E.V.,Smith, K.J.,Lewell, X.Q.,Rella, M.,White, G.V.,Polyakova, O.,Nassau, P.,Walker, A.L.,Holmes, D.S.,Pearce, A.C.,Wang, Y.,Liddle, J.,Hovnanian, A.
Evaluation of a crystallographic surrogate for kallikrein 5 in the discovery of novel inhibitors for Netherton syndrome.
Acta Crystallogr.,Sect.F, 75:385-391, 2019
PubMed: 31045568 (主引用文献が同じPDBエントリー)
DOI: 10.1107/S2053230X19003169
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (1.67 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2402 0.2% 0.5% 9.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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