6QD9

Leishmania major N-myristoyltransferase in complex with thienopyrimidine inhibitor IMP-0000065

6QD9 の概要

• エントリーDOI: 10.2210/pdb6qd9/pdb
• 関連するPDBエントリー: 4CGO
• 分子名称: Glycylpeptide N-tetradecanoyltransferase, TETRADECANOYL-COA, 3-[[2-[3-(dimethylamino)propyl-methyl-amino]thieno[3,2-d]pyrimidin-4-yl]-methyl-amino]propanenitrile, ... (5 entities in total)
• 機能のキーワード: transferase, myristoylation, benzothiophene, leishmania
• 由来する生物種: Leishmania major
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 49905.90

構造登録者

Brannigan, J.A. (登録日: 2019-01-01, 公開日: 2020-05-06, 最終更新日: 2024-01-24)

• 主引用文献: Bell, A.S.,Yu, Z.,Hutton, J.A.,Wright, M.H.,Brannigan, J.A.,Paape, D.,Roberts, S.M.,Sutherell, C.L.,Ritzefeld, M.,Wilkinson, A.J.,Smith, D.F.,Leatherbarrow, R.J.,Tate, E.W.; Novel Thienopyrimidine Inhibitors of Leishmania N -Myristoyltransferase with On-Target Activity in Intracellular Amastigotes.; J.Med.Chem., 63:7740-7765, 2020; PubMed: 32575985; DOI: 10.1021/acs.jmedchem.0c00570

実験手法

X-RAY DIFFRACTION (1.46 Å)