6QCN

Human Sirt2 in complex with ADP-ribose and the inhibitor quercetin

Summary for 6QCN

• Entry DOI: 10.2210/pdb6qcn/pdb
• Descriptor: NAD-dependent protein deacetylase sirtuin-2, ZINC ION, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, ... (5 entities in total)
• Functional Keywords: deacylase, substrate competitive inhibitor, isoform-selective, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 70529.40

Authors

Riemer, S.,You, W.,Steegborn, C. (deposition date: 2018-12-29, release date: 2019-12-25, Last modification date: 2024-01-24)

• Primary citation: You, W.,Zheng, W.,Weiss, S.,Chua, K.F.,Steegborn, C.; Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives.; Sci Rep, 9:19176-19176, 2019; PubMed: 31844103; DOI: 10.1038/s41598-019-55654-1

Experimental method

X-RAY DIFFRACTION (2.23 Å)