6QCN

Human Sirt2 in complex with ADP-ribose and the inhibitor quercetin

6QCN の概要

• エントリーDOI: 10.2210/pdb6qcn/pdb
• 分子名称: NAD-dependent protein deacetylase sirtuin-2, ZINC ION, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, ... (5 entities in total)
• 機能のキーワード: deacylase, substrate competitive inhibitor, isoform-selective, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70529.40

構造登録者

Riemer, S.,You, W.,Steegborn, C. (登録日: 2018-12-29, 公開日: 2019-12-25, 最終更新日: 2024-01-24)

• 主引用文献: You, W.,Zheng, W.,Weiss, S.,Chua, K.F.,Steegborn, C.; Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives.; Sci Rep, 9:19176-19176, 2019; PubMed: 31844103; DOI: 10.1038/s41598-019-55654-1

実験手法

X-RAY DIFFRACTION (2.23 Å)